Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PAK7 |
| Gene Name: | PAK7 |
| Protein Full Name: | Serine/threonine-protein kinase PAK 7 |
| Alias: | EC 2.7.11.1; KIAA1264; P21 protein (Cdc42/Rac)-activated kinase 7; P21-activated kinase 7; PAK 7; PAK-5; PAK7; PAK-7 |
| Mass (Da): | 80745 |
| Number AA: | 719 |
| UniProt ID: | Q9P286 |
| Locus ID: | 57144 |
| COSMIC ID: | PAK7 |
| Gene location on chromosome: | 20p12.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20619 |
| Percent of cancer specimens with mutations: | 1.59 |
| Normal role description: | PAK7 is a serine/theonine protein kinase activated by Rac/cdc42 and thus involved in regulation of cytoskeleton, cell surival and proliferation through RAF1 signalling. It phosphosphorylates BAD and prevents apoptosis. It is also involved in microtuble stablization, neurite outgrowth and development. It can destablize F-acting networks and eliminate stress fibres and focal adhesions. Pak7 expression provides a survival and could contribute to oncogenesis in this way. |