Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MST4 |
| Gene Name: | MST4 |
| Protein Full Name: | Serine/threonine-protein kinase MST4 |
| Alias: | EC 2.7.11.1; MASK; Serine/threonine protein kinase MST4 |
| Mass (Da): | 46529 |
| Number AA: | 416 |
| UniProt ID: | Q9P289 |
| Locus ID: | 51765 |
| COSMIC ID: | MST4 |
| Gene location on chromosome: | Xq26.2 |
| Cancer protein type: | BOTH |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20513 |
| Percent of cancer specimens with mutations: | 0.4 |
| Normal role description: | MST4 is a protein-serine/threonine kinase. It is activated by GM130 and can also be cleaved by caspase 3 in vitro. It has been implicated in cell growth by signalling in MAPK pathway and apoptotic pathways. In cancer over expression promotes cell proliferation and anchorage independent growth. |