Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NRXN2 |
| Gene Name: | NRXN2 |
| Protein Full Name: | Neurexin-2-alpha |
| Alias: | Neurexin 2; Neurexin II; Neurexin II-alpha; NRX2A |
| Mass (Da): | 184982 |
| Number AA: | 1712 |
| UniProt ID: | Q9P2S2/P58401 |
| Locus ID: | 9379 |
| COSMIC ID: | NRXN2 |
| Gene location on chromosome: | 11q13 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19926 |
| Percent of cancer specimens with mutations: | 1.76 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with some point mutations and 2 insertions, but no complex or deletion mutations. |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | NRXN2 is a cell surface protein on neurons that may play a role in cell recognition and adhesion. Its function in cancer is not well known. |
| Commentary on involvement of protein in cancer: | no entry in AGO; multiple uniprot IDs for different isoforms |