Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MBD2 |
| Gene Name: | MBD2 |
| Protein Full Name: | Methyl-CpG-binding domain protein 2 |
| Alias: | Methyl-CpG-binding domain protein 2: Methyl-CpG-binding protein MBD2: Demethylase: Methyl-CpG-binding domain protein 2: Methyl-CpG-binding protein MBD2: Demethylase; Methyl-CpG-binding protein MBD2 |
| Mass (Da): | 43255 |
| Number AA: | 411 |
| UniProt ID: | Q9UBB5 |
| Locus ID: | 8932 |
| COSMIC ID: | MBD2 |
| Gene location on chromosome: | 18q21.2 |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.24 |
| Commentary on involvement of protein in cancer: | Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemi-methylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Isoform 1 may enhance the activation of some unmethylated cAMP-responsive promoters. Reports about DNA demethylase activity of isoform 2 are contradictory. |