Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RNF7 |
| Gene Name: | RNF7 |
| Protein Full Name: | RING-box protein 2 |
| Alias: | CKII beta-binding protein 1;RING finger protein 7;Regulator of cullins 2;Sensitive to apoptosis gene protein |
| Mass (Da): | 12683 |
| Number AA: | 113 |
| UniProt ID: | Q9UBF6 |
| Locus ID: | 9616 |
| COSMIC ID: | RNF7 |
| Gene location on chromosome: | 3q22-24 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19805 |
| Percent of cancer specimens with mutations: | 0.09 |
| Normal role description: | RNF7 is a highly conserved ring-finger protein. It is an essential subunit of the SKP1-cullin/CDC53-F box ubiquitin ligase that functions as part of the protein degradation machinery involved in regulating cell-cyle protein turnover, and thus cell-cyle progression. Phosporylation of RNF7 by casein kinases II (CKII) leads to the degradation of p27Kip1 -- an inhibitor of cell-cycle progression -- implicating it as a possible tumour suppressor; however, upregulation of this gene has been found in lung and colon cancer, and expression levels negatively correlates with prognosis. |