Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DKK2 |
| Gene Name: | DKK2 |
| Mass (Da): | 28447 |
| Number AA: | 259 |
| UniProt ID: | Q9UBU2 |
| Locus ID: | 27123 |
| COSMIC ID: | DKK2 |
| Gene location on chromosome: | 4q25 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20234 |
| Percent of cancer specimens with mutations: | 0.82 |
| Commonly recorded point mutations: | C127R (7) |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | DKK2 can decrease Wnt signalling by inhibiting Wnt and LRP5/6 interaction and promote the internalization of LRP5/6. It plays an important role in vertebrate development and regulates antero-posterior axial patterning, limb development, somitogenesis, and eye formation. In the adult human, DKK2 may be involved in bone formation and disease, and cancer. It has been shown to promote angiogenesis in human endothelial cells. |