Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | GHRL |
| Gene Name: | GHRL |
| Protein Full Name: | Appetite-regulating hormone |
| Alias: | Appetite-regulating hormone precursor; Growth hormone secretagogue; Growth hormone-releasing peptide; M46 protein; Motilin-related peptide |
| Mass (Da): | 12911 |
| Number AA: | 117 |
| UniProt ID: | Q9UBU3 |
| Locus ID: | 51738 |
| COSMIC ID: | GHRL |
| Gene location on chromosome: | 3p26-p25 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.07 |
| Normal role description: | GHRL encodes for ghrelin-obestatin preproprotein, which generates ghrelin and obestatin. Ghrelin is a ligand for GHSR and is involved in regulating growth hormone release from the pituitary. It has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Obestatin is involved in inhibiting thirst and anxiety, improving memory, regulating sleep, affecting cell proliferation, and increasing the secretion of pancreatic juices. It may also have an appetite-reducing effect. |
| Commentary on involvement of protein in cancer: | Only 1 ovarian sample was included in Sanger COSMIC |