Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SEL1L |
| Gene Name: | SEL1L |
| Alias: | Suppressor of lin-12-like protein 1 |
| Mass (Da): | 88755 |
| Number AA: | 794 |
| UniProt ID: | Q9UBV2 |
| Locus ID: | 6400 |
| COSMIC ID: | SEL1L |
| Gene location on chromosome: | 14q24.3-q31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.61 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | SEL1L is a putative tumour suppressor that may play a negative role in Notch signalling. Overexpression of SEL1L in breast cancer cells reduced proliferative activity and invasiveness, while lack of expression was detected in 17% of pancreatic cancers. |