Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DMBT1 |
| Gene Name: | DMBT1 |
| Protein Full Name: | Deleted in malignant brain tumors 1 protein |
| Alias: | Glycoprotein 340;Hensin;Salivary agglutinin;Surfactant pulmonary-associated D-binding protein |
| Mass (Da): | 260735 |
| Number AA: | 2413 |
| UniProt ID: | Q9UGM3 |
| Locus ID: | 1755 |
| COSMIC ID: | DMBT1 |
| Gene location on chromosome: | 10q26.13 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBIT |
| Number of cancer specimens: | 19536 |
| Percent of cancer specimens with mutations: | 2.13 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | DMBT1 may play roles in mucosal defense system, cellular immune defense and epithelial differentiation, and also liver regeneration. It is required for terminal differentiation of columnar epithelial cells during embryonic development. Studies have suggested that rather than being a classical tumour suppressor gene via inhibition of proliferation, it may play a role in the interaction between tumour cells and the immune system. Defects in DMBT1 such as homozygous deletions have been associated with glioma and medulloblastoma. Other roles it may have include 1) opsonin receptor for SFTPD and SPAR in macrophages; 2) regulation of taste sensation; 3) inhibition and/or facilitation of HIV-1 transmission; defense against bacterial pathogens; 4) exocytosis and actin remodeling; 5) secretion of pancreatic zymogens. |