Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LIMD1 |
| Gene Name: | LIMD1 |
| Protein Full Name: | LIM domain-containing protein 1 |
| Alias: | LIM domains containing 1; LIM domains containing protein 1; LIMD |
| Mass (Da): | 72190 |
| Number AA: | 676 |
| UniProt ID: | Q9UGP4 |
| Locus ID: | 8994 |
| COSMIC ID: | LIMD1 |
| Gene location on chromosome: | 3p21.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19813 |
| Percent of cancer specimens with mutations: | 0.36 |
| Gene undergoes hypermethylation: | Yes in lung and H&N |
| Normal role description: | Co-repressor of cell proliferation with pRB and also functions as a repressor independantly. LIMD1 acts as a Snail co-repressor of E-cadherin signalling. Downregulated in many tumour systems supporting its role as TSP. |