Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ARMCX3 |
| Gene Name: | ARMCX3 |
| Protein Full Name: | Armadillo repeat-containing X-linked protein 3 |
| Alias: | ALEX3; armadillo repeat containing, X-linked 3; ARMX3; dJ545K15.2; DKFZp781N1954; KIAA0443; MGC12199 |
| Mass (Da): | 42501 |
| Number AA: | 379 |
| UniProt ID: | Q9UH62 |
| Locus ID: | 51566 |
| COSMIC ID: | ARMCX3 |
| Gene location on chromosome: | Xq22.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.3 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ARMCX3 is a single transmembrane protein containing three armadillo repeats, which is often involved in development, maintenance of tissue integrity, and tumorigenesis. Despite the presence of the armadillo repeats, loss of ARMCX3 expression has been associated with prostate, colon, pancreatic, and ovarian cancers, suggesting its potential role in tumour suppression instead. |