Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SWAP70 |
| Gene Name: | SWAP70 |
| Protein Full Name: | Switch-associated protein 70 |
| Alias: | KIAA0640; SWAP switching B-cell complex 70kDa subunit; SWAP-70; SWP70 |
| Mass (Da): | 68998 |
| Number AA: | 585 |
| UniProt ID: | Q9UH65 |
| Locus ID: | 23075 |
| COSMIC ID: | SWAP70 |
| Gene location on chromosome: | 11p15 |
| Number of cancer specimens: | 19720 |
| Percent of cancer specimens with mutations: | 0.33 |
| Commentary on involvement of protein in cancer: | Phosphatidylinositol 3,4,5-trisphosphate-dependent guanine nucleotide exchange factor (GEF) which, independently of RAS, transduces signals from tyrosine kinase receptors to RAC. It also mediates signaling of membrane ruffling. Regulates the actin cytoskeleton as an effector or adapter protein in response to agonist stimulated phosphatidylinositol (3,4)-bisphosphate production and cell protrusion |