Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MLX |
| Gene Name: | MLX |
| Protein Full Name: | Max-like protein X |
| Alias: | BHLHd13; BigMax protein; MAD7; Max-like bHLHZip protein; MXD7; Protein Mlx; TCFL4; Transcription factor-like 4; Transcription factor-like protein 4 |
| Mass (Da): | 33300 |
| Number AA: | 298 |
| UniProt ID: | Q9UH92 |
| Locus ID: | 6945 |
| COSMIC ID: | MLX |
| Gene location on chromosome: | 17q21.1 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.2 |
| Commentary on involvement of protein in cancer: | Transcription regulator. Forms a sequence-specific DNA-binding protein complex with MAD1, MAD4, MNT, WBSCR14 and MLXIP which recognizes the core sequence 5'-CACGTG-3'. The TCFL4-MAD1, TCFL4-MAD4, TCFL4-WBSCR14 complexes are transcriptional repressors. Plays a role in transcriptional activation of glycolytic target genes. Involved in glucose-responsive gene regulation. |