Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | STEAP1 |
| Gene Name: | STEAP1 |
| Protein Full Name: | Metalloreductase STEAP1 |
| Alias: | PRSS24; six transmembrane epithelial antigen of prostate 1; six transmembrane epithelial antigen of the prostate; six transmembrane epithelial antigen of the prostate 1; STEA1; STEAP |
| Mass (Da): | 39851 |
| Number AA: | 339 |
| UniProt ID: | Q9UHE8 |
| Locus ID: | 26872 |
| COSMIC ID: | STEAP1 |
| Gene location on chromosome: | 7q21.13 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20057 |
| Percent of cancer specimens with mutations: | 0.3 |
| Normal role description: | STEAP1 is a cell membrane protein that is overexpressed in various cancer systems (prostate, breast, pancreas, bladder, gastrointestinal tract, testis, ovary, cervix, Ewing sarcoma, and melanomas). Thought to facilitate cell-cell interactions of tumors and possible even intercellular transport. |