Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | HERC5 |
| Gene Name: | HERC5 |
| Alias: | Cyclin-E-binding protein 1;HECT domain and RCC1-like domain-containing protein 5 |
| Mass (Da): | 116852 |
| Number AA: | 1024 |
| UniProt ID: | Q9UII4 |
| Locus ID: | 51191 |
| COSMIC ID: | HERC5 |
| Gene location on chromosome: | 4q22.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20150 |
| Percent of cancer specimens with mutations: | 0.85 |
| Normal role description: | HERC5 is part of the innate immune system and acts as a positive regulator of innate antiviral response in cells induced by interferon. Induces CDK activity in a p53-independent fashion. Role in oncogenesis unclear but likely mediated via CDK pathways. |