Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SIX4 |
| Gene Name: | SIX4 |
| Protein Full Name: | Homeobox protein SIX4 |
| Alias: | AREC3; homeobox SIX4 |
| Mass (Da): | 80832 |
| Number AA: | 781 |
| UniProt ID: | Q9UIU6 |
| Locus ID: | 51804 |
| COSMIC ID: | SIX4 |
| Gene location on chromosome: | 14q23 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19788 |
| Percent of cancer specimens with mutations: | 0.6 |
| Normal role description: | SIX4 is a nuclear localized transcription factor required for embryonic development and differentiation of neuronal cells. Mis-sense mutations have been identified in this gene and correlate with breast cancer. These mutations however have not been functionally characterized. |
| Commentary on involvement of protein in cancer: | No entry in Atlasgeneticsoncology.org |