Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ERRFI1 |
| Gene Name: | ERRFI1 |
| Protein Full Name: | ERBB receptor feedback inhibitor 1 |
| Alias: | ERRFI; GENE-33; MIG6; MIG-6; Mitogen-inducible gene 6 protein; RALT |
| Mass (Da): | 50560 |
| Number AA: | 462 |
| UniProt ID: | Q9UJM3 |
| Locus ID: | 54206 |
| COSMIC ID: | ERRFI1 |
| Gene location on chromosome: | 1p36.23 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.37 |
| Normal role description: | Negative regulator of EGFR mediated signalling through blocking EGFR receptor dimerization. ERRFI1 inhibits Met-mediated cell migration. Suggested to act as a tumour suppressor. Reduced expression levels have been observed in a variety of human cancers. |