Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | IKZF2 |
| Gene Name: | IKZF2 |
| Protein Full Name: | Ikaros family zinc finger protein 2 |
| Alias: | HELI; HELIOS; Zinc finger protein Helios; ZNFN1A2 |
| Mass (Da): | 59574 |
| Number AA: | 526 |
| UniProt ID: | Q9UKS7 |
| Locus ID: | 22807 |
| COSMIC ID: | IKZF2 |
| Gene location on chromosome: | 2q34 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19990 |
| Percent of cancer specimens with mutations: | 0.55 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | IKZF2 is a zinc finger protein that can associate with the protein Ikaros at centromeric heterochromatin. It is thought to be involved In lymphocyte development and early hematopoietic development. Its function in cancer is unknown, but overexpression in B cells of mice promoted lymphomagenesis. |