Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ITGA11 |
| Gene Name: | ITGA11 |
| Protein Full Name: | Integrin alpha-11 precursor |
| Alias: | HsT18964; integrin alpha-11; integrin, alpha 11; ITA11 |
| Mass (Da): | 133610 |
| Number AA: | 1189 |
| UniProt ID: | Q9UKX5 |
| Locus ID: | 22801 |
| COSMIC ID: | ITGA11 |
| Gene location on chromosome: | 15q23 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 20115 |
| Percent of cancer specimens with mutations: | 1 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | ITGA11 is a cell-surface receptor for collagen in the extracellular matrix. It may be involved in cell attachment, migration, and collagen reorganization on mesenchymal non-muscle cells. Overexpression of ITGA11 was implicated in non-small cell lung cancer. It appears that increased expression can also upregulate IGF2, which can in turn stimulate tumour epithelial cell growth and metastasis. |