Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | INTS6 |
| Gene Name: | INTS6 |
| Protein Full Name: | Integrator complex subunit 6 |
| Alias: | DBI-1; DDX26; DDX26A; DEAD box protein; DEAD/H (Asp-Glu-Ala-Asp/His) box polypeptide 26; DICE1; HDB; INT6; Integrator complex subunit 6: Protein deleted in cancer 1: Protein DDX26: DBI-1: Integrator complex subunit 6, isoform CRAa: Putative uncharacterized protein INTS6; Notchl2; RNA helicase HDB |
| Mass (Da): | 100390 |
| Number AA: | 887 |
| UniProt ID: | Q9UL03 |
| Locus ID: | 26512 |
| COSMIC ID: | INTS6 |
| Gene location on chromosome: | 13q14.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.61 |
| Gene undergoes hypermethylation: | Lung & prostate cancer |
| Normal role description: | INTS6 is an RNA helicase and a DEAD box protein that is part of a complex interacting with the C-terminus of RNA polymerase II. It is involved in 3' end processing of snRNAs and is a candidate tumour suppressor located in the critical region of loss of heterozygosity. |