Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZMIZ1 |
| Gene Name: | ZMIZ1 |
| Protein Full Name: | Zinc finger MIZ domain-containing protein 1 |
| Alias: | PIAS-like hZimp10; PIAS-like Zimp10; Retinoic acid induced 17; Retinoic acid-induced 17; ZIMP10; Zinc finger-containing, Miz1, PIAS-like protein on chromosome 10; ZMIZ1 |
| Mass (Da): | 115483 |
| Number AA: | 1067 |
| UniProt ID: | Q9ULJ6 |
| Locus ID: | 57178 |
| COSMIC ID: | ZMIZ1 |
| Gene location on chromosome: | 10q22.3 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19782 |
| Percent of cancer specimens with mutations: | 0.98 |
| Deregulated in translocations: | t(9;10)(q34;q22.3); ZMIZ1-ABL1 in ALL |
| Normal role description: | This gene encodes a member of the PIAS (protein inhibitor of activated STAT) family of proteins. The encoded protein may also play a role in sumoylation. ZIMZ1 regulates the activity of various transcription factors, including the androgen receptor, Smad3/4, and p53. Thus, ZIMZ1 appears to have different roles in oncogenesis depending on which particular target protein pre-dominates in the cancer system. |