Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SYNPO2 |
| Gene Name: | SYNPO2 |
| Protein Full Name: | Synaptopodin 2 |
| Alias: | Synaptopodin 2;Myopodin isoform 2;Synaptopodin-2;Myopodin;Genethonin-2 |
| Mass (Da): | 136352 |
| Number AA: | 1261 |
| UniProt ID: | Q9UMS6 |
| Locus ID: | 171024 |
| COSMIC ID: | SYNPO2 |
| Gene location on chromosome: | 4q26; 4q27 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 1.23 |
| Normal role description: | SYNPO2 is an actin associated protein which may function in bundling of actin filaments. This protein may have a role in regulating the shape and motility of cells through regulating actin dynamics. This protein may have tumour suppressor function as deletion of SYNPO2 has been implicated with more aggressive types of Prostate cancer and urothelial cell carcinoma. |