Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NENF |
| Gene Name: | NENF |
| Protein Full Name: | Neudesin |
| Alias: | CIR2; Neuron-derived neurotrophic factor; SCIRP10 |
| Mass (Da): | 18856 |
| Number AA: | 172 |
| UniProt ID: | Q9UMX5 |
| Locus ID: | 29937 |
| COSMIC ID: | NENF |
| Gene location on chromosome: | 1q32. |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.12 |
| Commentary on involvement of protein in cancer: | Displays neurotrophic activity and activates phosphorylation of MAPK1/ERK2, MAPK3/ERK1 and AKT1/AKT in primary cultured neurons. Does not have mitogenic activity in primary cultured astrocytes. May play a role on neuronal differentiation and may have a transient effect on neural cell proliferation in neural precursor cells. Neurotrophic activity is enhanced by binding to heme |