Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | NDRG2 |
| Gene Name: | NDRG2 |
| Protein Full Name: | Protein NDRG2 |
| Alias: | KIAA1248; NDR2; NDRG family member 2; NDRG2 protein; Protein Syld709613; SYLD; Syld709613 protein |
| Mass (Da): | 40798 |
| Number AA: | 371 |
| UniProt ID: | Q9UN36 |
| Locus ID: | 57447 |
| COSMIC ID: | NDRG2 |
| Gene location on chromosome: | 14q11.2 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19691 |
| Percent of cancer specimens with mutations: | 0.32 |
| Normal role description: | NDRG2 is part fo the N-myc downregulated gene (NDRG) family. It is a cytosolic protein that may play a role in neurite outgrowth. Downregulation of this gene has been found in liver, brain, and stomach tumors. |