Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ING4 |
| Gene Name: | ING4 |
| Protein Full Name: | Inhibitor of growth protein 4 |
| Alias: | My036 protein; P29ING4 |
| Mass (Da): | 28530 |
| Number AA: | 249 |
| UniProt ID: | Q9UNL4 |
| Locus ID: | 51147 |
| COSMIC ID: | ING4 |
| Gene location on chromosome: | 12p13.31 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.23 |
| Normal role description: | ING4 is a tumour suppressor involved in chromatin remodelling. It binds p53 and p300, - a component of the histone acetyl transferase (HAT) complex, suggesting that it may be involved in the p53-dependent regulatory pathway. It also functions as a repressor of factors that mediate angiogenesis, and it may be involved in innate immunity by regulating the levels of IκB and NFκB and the activation of select cytokine promoters. It is downregulated in a number of cancers. |
| Commentary on involvement of protein in cancer: | 3/468 (1%) of CNS tumours were also mutated; only 1 ovarian sample was included in Sanger COSMIC |