Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | USP24 |
| Gene Name: | USP24 |
| Protein Full Name: | Ubiquitin carboxyl-terminal hydrolase 24 |
| Alias: | Deubiquitinating enzyme 24; KIAA1057; UB24; Ubiquitin specific peptidase 24; Ubiquitin specific protease 24; Ubiquitin thiolesterase 24; Ubiquitin-specific processing protease 24; UBP24 |
| Mass (Da): | 294365 |
| Number AA: | 2620 |
| UniProt ID: | Q9UPU5 |
| Locus ID: | 23358 |
| COSMIC ID: | USP24 |
| Gene location on chromosome: | 1p32.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20092 |
| Percent of cancer specimens with mutations: | 1.25 |
| Normal role description: | USP24 is a protease that plays a role in the ubiquitin-dependent proteolytic pathway in conjunction with the 26S proteasom. It can carry out thiol-dependent hydrolysis of: ester, thioester, amide, peptide and isopeptide bonds. Mutations in this gene have been observed in breast and ovarian tumors. |