Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CORO2B |
| Gene Name: | CORO2B |
| Alias: | Coronin-like protein C;Protein FC96 |
| Mass (Da): | 54953 |
| Number AA: | 480 |
| UniProt ID: | Q9UQ03 |
| Locus ID: | 10391 |
| COSMIC ID: | CORO2B |
| Gene location on chromosome: | 15q23 |
| Cancer protein type: | OP (possibly) |
| Effect of cancer mutation on protein: | GAIN (possibly) |
| Effect of active protein on cancer: | PROMOTES (possibly) |
| Number of cancer specimens: | 19689 |
| Percent of cancer specimens with mutations: | 0.57 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | CORO2B may take part in neuronal actin structure organization. It accumulates at the leading edges of motile cells and is also involved in cell motility, cytokinesis, and phagocytosis. A P318L mutation has been associated with a colorectal cancer sample. |
| Commentary on involvement of protein in cancer: | no entry in AGO |