Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CNTN6 |
| Gene Name: | CNTN6 |
| Protein Full Name: | Contactin-6 |
| Alias: | Contactin 6; NB3; NB-3; Neural adhesion molecule; Neural recognition molecule NB-3 |
| Mass (Da): | 113956 |
| Number AA: | 1028 |
| UniProt ID: | Q9UQ52 |
| Locus ID: | 27255 |
| COSMIC ID: | CNTN6 |
| Gene location on chromosome: | 3p26-p25 |
| Cancer protein type: | TSP (possibly) |
| Effect of cancer mutation on protein: | LOSS (possibly) |
| Effect of active protein on cancer: | INHIBIT (possibly) |
| Number of cancer specimens: | 19999 |
| Percent of cancer specimens with mutations: | 2.04 |
| Mutations observed as inherited: | NA |
| Found in amplified chromosomal regions in human cancers: | NA |
| Deregulated in translocations: | NA |
| Deregulated by viral insertion: | NA |
| Transduced into viral genome: | NA |
| Gene undergoes hypermethylation: | NA |
| Normal role description: | CNTN6 is a contactin adhesion protein, part of the immunoglobulin superfamily, that mediates cell surface interactions, especially during nervous system development. It is anchored to the membrane through glycosylphosphatidylinositol anchoring. It can also act as a ligand for NOTCH1, promoting its activation and release of its intracellular domain for translocation to the nucleus. T108A and S585C mutations have been found in breast cancer samples. |