Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | CTNND2 |
| Gene Name: | CTNND2 |
| Protein Full Name: | Catenin delta-2 |
| Alias: | Catenin, delta 2; CTND2; Delta-catenin; GT24; Neural plakophilin-related ARM-repeat protein; Neurojungin; NPRAP |
| Mass (Da): | 132656 |
| Number AA: | 1225 |
| UniProt ID: | Q9UQB3 |
| Locus ID: | 1501 |
| COSMIC ID: | CTNND2 |
| Gene location on chromosome: | 5p15.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19904 |
| Percent of cancer specimens with mutations: | 2.4 |
| Normal role description: | Catenin forms an adhesive junction associated protein of the armadillo/beta-catenin superfamil; it is implicated in brain and eye development, as well as cancer formation. It funtions to disruption of E-cadherin-based adherens junction, which favors cell spreading after stimulation by hepatocyte growth factor. It is associate with colon, lung, ovarian, and skin cancer. |
| Commentary on involvement of protein in cancer: | Functions as a transcriptional activator when bound to ZBTB33. May be involved in neuronal cell adhesion and tissue morphogenesis and integrity by regulating adhesion molecules. |