Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TNN |
| Gene Name: | TNN |
| Mass (Da): | 144034 |
| Number AA: | 1299 |
| UniProt ID: | Q9UQP3 |
| Locus ID: | 63923 |
| COSMIC ID: | TNN |
| Gene location on chromosome: | 1q25.1 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19674 |
| Percent of cancer specimens with mutations: | 2.19 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with several point mutations, but no complex, insertion or deletion mutants. |
| Normal role description: | TNN is an extracellular protein involved in fibroblast physiology. TNN permits the migration of cells within the ECM. This role is correlated with increased TNN expression in malignant stroma compared to normal control tissue. This likely correlates with the increased propensity of tumors to spread throughout the ECM. |