Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DMTF1 |
| Gene Name: | DMTF1 |
| Alias: | Cyclin-D-interacting Myb-like protein 1 |
| Mass (Da): | 84471 |
| Number AA: | 760 |
| UniProt ID: | Q9Y222 |
| Locus ID: | 9988 |
| COSMIC ID: | DMTF1 |
| Gene location on chromosome: | 7q21.12 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.48 |
| Gene undergoes hypermethylation: | Promoter hypermethylation in human non-small-cell lung carcinomas (2%). |
| Normal role description: | DMTF1 is a transcription factor which activates the ARF-p53 signalling pathway to cause growth arrest or induce apoptosis. DMTF1 is activated in response to Ras-Raf signalling and is regulated by the D-cyclins. DMTF1 thereby acts primarily as a tumour suppressor protein. Loss of heterozygosity for the DMTF1 gene results in the development of lung cancers and leukemias in human and mouse models. |
| Commentary on involvement of protein in cancer: | Less than 3% mutation in CNS. |