Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | RUVBL2 |
| Gene Name: | RUVBL2 |
| Protein Full Name: | RuvB-like 2 |
| Alias: | 48-kDa TATA box-binding protein-interacting protein; 48-kDa TBP-interacting protein; 51 kDa erythrocyte cytosolic protein; ECP51; ECP-51; INO80 complex subunit J; INO80J; Repressing pontin 52; Reptin; Reptin 52; Reptin52; RUVB2; Rvb2; RVB2; TAP54-beta; TIH2; TIP48; TIP49b; TIP60-associated protein 54-beta |
| Mass (Da): | 51157 |
| Number AA: | 463 |
| UniProt ID: | Q9Y230 |
| Locus ID: | 10856 |
| COSMIC ID: | RUVBL2 |
| Gene location on chromosome: | 19q13.33 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19718 |
| Percent of cancer specimens with mutations: | 0.01 |
| Normal role description: | Possesses single-stranded DNA-stimulated ATPase and ATP-dependent DNA helicase (5' to 3') activity. Interacts with c-myc oncogene to transcribe various gene targets. Also modulates transcriptional regulation by the beta-catenin/TCF-LEF complex. Upregulated in numerous cancer systems. Oncogenesis likely meditated via c-myc and beta-catenin pathway upregulation |