Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | APOBEC2 |
| Gene Name: | APOBEC2 |
| Mass (Da): | 25703 |
| Number AA: | 224 |
| UniProt ID: | Q9Y235 |
| Locus ID: | 10930 |
| COSMIC ID: | APOBEC2 |
| Gene location on chromosome: | 6p21 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.25 |
| Normal role description: | APOBEC2 may be involved in epigenetic regulation via DNA methylation. It was suggested to be a member of the C -> U editing enzyme subfamily of he cytidine deaminase supergene family. However it does not show any detectable apolipoprotein B mRNA editing, but low intrinsic deaminase activity. APOBEC2 expression was shown to be upregulated in response to proinflammatory cytokines in hepatocytes and might facilitate hepatocellular carcinoma. |
| Commentary on involvement of protein in cancer: | No transforming mutations were identified in the Atlas of Gene Oncology, the Sanger COSMIC database, or Uniprot for this gene. |