Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AKT3 |
| Gene Name: | AKT3 |
| Protein Full Name: | RAC-gamma serine/threonine-protein kinase |
| Alias: | Akt3; EC 2.7.11.1; Kinase Akt3; PKB gamma; PKBG; PRKBG; Protein kinase Akt-3; Protein kinase B, gamma; RAC-gamma; RAC-gamma serine,threonine protein kinase; RAC-gamma serine/threonine protein kinase; RAC-PK-gamma; STK-2; V-akt murine thymoma viral oncogene 3 |
| Mass (Da): | 55775 |
| Number AA: | 479 |
| UniProt ID: | Q9Y243 |
| Locus ID: | 10000 |
| COSMIC ID: | AKT3 |
| Gene location on chromosome: | 1q44 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 21208 |
| Percent of cancer specimens with mutations: | 0.51 |
| Normal role description: | AKT3 is Ser/Thr Kinase that is activated by PIP2 produced by PI3K, leading to translocation of AKT3 to the plasma membrane where it can be activated by S/T phosphorylation by PDK1/2. It is a regulator of cell signalling events such as proliferation, differentiation, apoptosis, tumorigenesis and also plays a role in brain development and in glucose metabolism, in response to insulin and a variety of growth factors such as PDGF and IGF-1. It is upregulated in a number of cancers. |
| Commentary on involvement of protein in cancer: | Only 4 unique mutations (out of 1414 samples) were documented on Sanger COSMIC. 1 CNS, 1 breast and 1 lung sample were mutated but all represented <1% of total samples for that tissue. |