Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | BTRC |
| Gene Name: | BTRC |
| Protein Full Name: | F-box/WD repeat-containing protein 1A |
| Alias: | Beta-TRCP; E3RSIkappaB; F-box and WD-repeats protein Beta-TrCP; F-box/WD-repeat protein 1A; FBW1A; PIkappaBalpha-E3 receptor subunit |
| Mass (Da): | 68867 |
| Number AA: | 605 |
| UniProt ID: | Q9Y297 |
| Locus ID: | 8945 |
| COSMIC ID: | BTRC |
| Gene location on chromosome: | 10q24.32 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20237 |
| Percent of cancer specimens with mutations: | 0.52 |
| Normal role description: | BTRC is a F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. Mutations in BTrCP in both germinal and somatic cells are rarely found in human tumors, this is likley due to the redundancy of the two BTrCP proteins. |
| Commentary on involvement of protein in cancer: | Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. Recognizes and binds to phosphorylated target proteins. SCF(BTRC) mediates the ubiquitination of CTNNB1 and participates in Wnt signaling. SCF(BTRC) mediates the ubiquitination of NFKBIA, NFKBIB and NFKBIE; the degradation frees the associated NFKB1 to translocate into the nucleus and to activate transcription. Ubiquitination of NFKBIA occurs at 'Lys-21' and 'Lys-22'. SCF(BTRC) mediates the ubiquitination of phosphorylated NFKB1/nuclear factor NF-kappa-B p105 subunit, ATF4, SMAD3, SMAD4, CDC25A, DLG1, FBXO5 and probably NFKB2. SCF(BTRC) mediates the ubiquitination of phosphorylated SNAI1. May be involved in ubiquitination and subsequent proteasomal degradation through a DBB1-CUL4 E3 ubiquitin-protein ligase. Required for activation of NFKB-mediated transcription by IL1B, MAP3K14, MAP3K1, IKBKB and TNF. Required for proteolytic processing of GLI3. |