Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ATF5 |
| Gene Name: | ATF5 |
| Alias: | Activating transcription factor 5;Transcription factor ATFx |
| Mass (Da): | 30690 |
| Number AA: | 282 |
| UniProt ID: | Q9Y2D1 |
| Locus ID: | 22809 |
| COSMIC ID: | ATF5 |
| Gene location on chromosome: | 19q13.33 |
| Cancer protein type: | OP/TSP |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.28 |
| Normal role description: | ATF5 is a transcriptional activator which binds the cAMP response element (CRE), which is present in many cellular (and viral) promoters, leading to DNA transcription. It regulates cell cycle progression, differentiation, metabolite homeostasis, and apoptosis, as well as proliferation and differentiation of neural cells. |
| Commentary on involvement of protein in cancer: | ATF5 is upregulated in a number of cancers but downregulated in liver cancer, indicating that its tumour specific role is tissue dependent. |