Cancer Protein Description

This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.


Protein Name: PADI2
Gene Name: PADI2
Alias: PAD-H19;Peptidylarginine deiminase II;Protein-arginine deiminase type II
Mass (Da): 75564
Number AA: 665
UniProt ID: Q9Y2J8
Locus ID: 11240
COSMIC ID: PADI2
Gene location on chromosome: 1p36.13
Cancer protein type: UNCLEAR
Effect of cancer mutation on protein: UNCLEAR
Effect of active protein on cancer: UNCLEAR
Number of cancer specimens: 19695
Percent of cancer specimens with mutations: 0.7
Mutations observed as inherited: NA
Found in amplified chromosomal regions in human cancers: NA
Deregulated in translocations: NA
Deregulated by viral insertion: NA
Transduced into viral genome: NA
Gene undergoes hypermethylation: NA
Normal role description: PADI2 is a protein arginine deiminase that catalyzes the deimination of arginine residues and consequent conversion to citrullines on proteins. Its function in cancer is unknown.


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