Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | AXIN2 |
| Gene Name: | AXIN2 |
| Protein Full Name: | Axin-2 |
| Alias: | Axil; Axin 2; Axin-like protein; Axis inhibition protein 2; AXN2; Conductin; DKFZp781B0869; MGC126582 |
| Mass (Da): | 93558 |
| Number AA: | 843 |
| UniProt ID: | Q9Y2T1 |
| Locus ID: | 8313 |
| COSMIC ID: | AXIN2 |
| Gene location on chromosome: | 17q24.1 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 20209 |
| Percent of cancer specimens with mutations: | 0.89 |
| Gene undergoes hypermethylation: | Yes in colorectal cancer |
| Normal role description: | Axin2 functions to inhibit the Wnt/TCF pathway as a member of the beta-catenin destruction complex. Thus, functioning as a tumour suppresor gene, Axin2 will mitigate the oncogenic potential of the Wnt/TCF pathway. |