Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | MAP3K2 |
| Gene Name: | MAP3K2 |
| Protein Full Name: | Mitogen-activated protein kinase kinase kinase 2 |
| Alias: | EC 2.7.11.25; Kinase MEKK2; M3K2; MAP/ERK kinase kinase 2; MAP3K2; MAPK/ERK kinase kinase 2; MAPKKK2; MEK kinase 2; MEKK 2; MEKK2B |
| Mass (Da): | 69741 |
| Number AA: | 619 |
| UniProt ID: | Q9Y2U5 |
| Locus ID: | 10746 |
| COSMIC ID: | MAP3K2 |
| Gene location on chromosome: | 2q14.3 |
| Number of cancer specimens: | 20472 |
| Percent of cancer specimens with mutations: | 0.34 |
| Normal role description: | MAP3K2 is a protein-serine/threonine kinase. |
| Commentary on involvement of protein in cancer: | Component of a protein kinase signal transduction cascade. Regulates the JNK and ERK5 pathways by phosphorylating and activating MAP2K5 and MAP2K7 By similarity. Plays a role in caveolae kiss-and-run dynamics. |