Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | THRAP3 |
| Gene Name: | THRAP3 |
| Protein Full Name: | Thyroid hormone receptor-associated protein 3 |
| Alias: | T150; Thyroid hormone receptor associated protein 3; Thyroid hormone receptor associated protein 3 (TRAP150); Thyroid hormone receptor-associated protein complex 150 kDa component; TR150; TRAP150 |
| Mass (Da): | 108666 |
| Number AA: | 955 |
| UniProt ID: | Q9Y2W1 |
| Locus ID: | 9967 |
| COSMIC ID: | THRAP3 |
| Gene location on chromosome: | 1p34.3 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20238 |
| Percent of cancer specimens with mutations: | 0.85 |
| Normal role description: | THRAP3 is a subunit of the large multiprotein complex TRAP, and functions as a transcriptional co-activator. Its role in oncogenesis is currently unknown. |
| Commentary on involvement of protein in cancer: | 1/185 breast- and 3/145 lung cancer samples were also mutated (Sanger COSMIC) |