Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | ZNF281 |
| Gene Name: | ZNF281 |
| Protein Full Name: | Zinc finger protein 281 |
| Alias: | GC-box-binding zinc finger protein 1; GZP1; Transcription factor ZBP-99; ZBP99; ZBP-99; Zinc finger DNA binding protein 99; Zinc finger DNA-binding protein 99; ZN281; ZNP-99; ZNP-99 transcription factor |
| Mass (Da): | 96915 |
| Number AA: | 895 |
| UniProt ID: | Q9Y2X9 |
| Locus ID: | 23528 |
| COSMIC ID: | ZNF281 |
| Gene location on chromosome: | 1q32.1 |
| Number of cancer specimens: | 19688 |
| Percent of cancer specimens with mutations: | 0.58 |
| Normal role description: | Transcription protein- repressor. Involved in transcriptional regulation. Represses the transcription of a number of genes including gastrin and ornithine decarboxylase. Binds to the G-rich box in the enhancer region of these genes. |
| Commentary on involvement of protein in cancer: | no entry in AGO |