Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KLK5 |
| Gene Name: | KLK5 |
| Protein Full Name: | Kallikrein-5 |
| Alias: | Kallikrein-like protein 2;Stratum corneum tryptic enzyme |
| Mass (Da): | 32019 |
| Number AA: | 293 |
| UniProt ID: | Q9Y337 |
| Locus ID: | 25818 |
| COSMIC ID: | KLK5 |
| Gene location on chromosome: | 19q13.41 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19717 |
| Percent of cancer specimens with mutations: | 0.45 |
| Normal role description: | Secreted serine protease. Plays a role in skin desquamation and can digest ECM components, such as collagen, laminin and fibronectin. Activates KLK7. However its role in tumorigenesis and its physiological function are not fully understood. Upregulated in ovarian, breast and bladder cancer, downregulated in prostate, testicular and NSCLC. |
| Commentary on involvement of protein in cancer: | No mutations have been reported on the Atlas of Genetics in Oncology or the SANGER COSMIC database. |