Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | SH3BP1 |
| Gene Name: | SH3BP1 |
| Protein Full Name: | SH3 domain-binding protein 1 |
| Alias: | 3BP1; dJ37E16.2; SH3 domain binding protein 1; SH3-domain binding protein 1 |
| Mass (Da): | 75713 |
| Number AA: | 701 |
| UniProt ID: | Q9Y3L3 |
| Locus ID: | 23616 |
| COSMIC ID: | SH3BP1 |
| Gene location on chromosome: | 22q13.1 |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.46 |
| Commentary on involvement of protein in cancer: | Binds differentially to the SH3 domains of certain proteins of signal transduction pathways. This protein binds preferentially to the ABL1 proto-oncogene, SRC and GRB2. Shows GAP activity for Rac-related proteins but not for Rho- or Ras-related proteins. It inhibits PDGF-induced membrane ruffling mediated by Rac |