Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | StARD13 |
| Gene Name: | STARD13 |
| Protein Full Name: | StAR-related lipid transfer protein 13 |
| Alias: | 46H23.2; Deleted in liver cancer 2; Deleted in liver cancer protein 2; DLC2; GT650; Rho GTPase activating protein on chromosome 13q12; Rho GTPase-activating protein; STA13; StAR-related lipid transfer (START) domain containing 13; START domain containing 13; START domain- containing protein 13; START domain-containing protein 13 |
| Mass (Da): | 124967 |
| Number AA: | 1113 |
| UniProt ID: | Q9Y3M8 |
| Locus ID: | 90627 |
| COSMIC ID: | STARD13 |
| Gene location on chromosome: | 13q13.3 |
| Cancer protein type: | TSP |
| Effect of cancer mutation on protein: | LOSS |
| Effect of active protein on cancer: | INHIBITS |
| Number of cancer specimens: | 19625 |
| Percent of cancer specimens with mutations: | 0.92 |
| Normal role description: | STARD13 functions as a GTPase-activating protein for RhoA, and possibly for Cdc42, as well. It may play a role in the regulation of cytoskeletal re-organization, cell proliferation, and cell motility. The gene is located in a region of chromosome 13 that is associated with loss of heterozygosity in hepatocellular carcinomas. |
| Commentary on involvement of protein in cancer: | 1/1 (100%) laryngeal tumour sample was also mutated (mis-sense) |