Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | DYRK1B |
| Gene Name: | DYRK1B |
| Protein Full Name: | Dual specificity tyrosine-phosphorylation-regulate |
| Alias: | Dual-specificity tyrosine- (Y)-phosphorylation regulated kinase 1B; Dual-specificity tyrosine-phosphorylation regulated kinase 1B; DYR1B; EC 2.7.12.1; Kinase DYRK1B; Minibrain-related kinase; MIRK; Mirk protein kinase |
| Mass (Da): | 69198 |
| Number AA: | 629 |
| UniProt ID: | Q9Y463 |
| Locus ID: | 9149 |
| COSMIC ID: | DYRK1B |
| Gene location on chromosome: | 19q12-q13.1; 19q13.2 |
| Cancer protein type: | OP |
| Effect of cancer mutation on protein: | GAIN |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19949 |
| Percent of cancer specimens with mutations: | 0.51 |
| Found in amplified chromosomal regions in human cancers: | Ductal adenocarcinomas of pancreas (10%) |
| Normal role description: | DYRK1B is a dual specificity protein serine/threonine and tyrosine kinase. DYRK1B is nuclear localized and is found to enhance transcriptional activity of transcription factors such as TCF1 and FOXO1. DYRK1B is expressed primarily in muscle and testis and is thought to have a role in myoblast differentiation. Increased activity of DYRK1B was observed in rhabdomyosarcoma, colon and pancreatic cancers. Amplification of the DYRK1B gene was observed in 10% of pancreatic cancer cell lines. Overexpression of DYRK1B was found to enhance cell proliferation independent of mitogen stimulation in colon cancers. |
| Commentary on involvement of protein in cancer: | Less than 3% mutations in CNS. |