Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | PRKAB1 |
| Gene Name: | PRKAB1 |
| Protein Full Name: | 5'-AMP-activated protein kinase subunit beta-1 |
| Alias: | 5'-AMP-activated protein kinase, beta-1 subunit; AAKB1; AMPK beta 1; AMPK beta-1 chain; AMPK-beta1; Kinase AMPK-beta1; Protein kinase, AMP-activated, beta 1 non-catalytic subunit |
| Mass (Da): | 30382 |
| Number AA: | 270 |
| UniProt ID: | Q9Y478 |
| Locus ID: | 5564 |
| COSMIC ID: | PRKAB1 |
| Gene location on chromosome: | 12q24.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20337 |
| Percent of cancer specimens with mutations: | 0.27 |
| Normal role description: | PRKAB1 is a protein-serine/threonine kinase - regulatory subunit of AMP-activated protein kinase (AMPK). AMPK senses low intracellular energy levels upon increased AMP/ATP ratio. Binding of AMP to AMPK activates the heterotrimeric kinase and leads to modulation of downstream pathways. PRKAB1 and PRKAB2 contain a glycogen binding domain that may target AMPK to glycogen. Expression of PRKAB1 and PRKAB2 may be regulated by p53. |
| Commentary on involvement of protein in cancer: | No mutations reported on the Sanger COSMIC database or the Atlas of Oncology. |