Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | TRRAP |
| Gene Name: | TRRAP |
| Protein Full Name: | Transformation/transcription domain-associated pro |
| Alias: | 350,400 kDa PCAF-associated factor; 350/400 kDa PCAF-associated factor; PAF350,400; PAF350/400; PAF400; STAF40; Tra1; Transformation/transcription domain-associated; TRAP; TR-AP |
| Mass (Da): | 437600 |
| Number AA: | 3859 |
| UniProt ID: | Q9Y4A5 |
| Locus ID: | 8295 |
| COSMIC ID: | TRRAP |
| Gene location on chromosome: | 7q22.1 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 20162 |
| Percent of cancer specimens with mutations: | 3.01 |
| General distribution of mutations: | Multi-site |
| Location of most mutations: | Broad distribution of mutation sites with many point mutations, but no deletions, insertions or complex mutations across the entire protein. |
| Normal role description: | TRRAP is an adapter protein involved in histone acetylation. It is involved in regulation of MYC, p53, E2F1, and E2F4 transcription activation and DNA repair. Its role may also be required for cell cycle progression. |