Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | KDM3A |
| Gene Name: | KDM3A |
| Protein Full Name: | Lysine-specific demethylase 3A |
| Alias: | JHD2A; JHMD2A; JMJ1A; JmjC domain-containing histone demethylation protein 2A; JMJD1; Jumonji C domain-containing histone demethylase 2A; Jumonji domain-containing protein 1A; KIAA0742; Lysine (K)-specific demethylase 3A; TSGA |
| Mass (Da): | 147327 |
| Number AA: | 1321 |
| UniProt ID: | Q9Y4C1 |
| Locus ID: | 55818 |
| COSMIC ID: | KDM3A |
| Gene location on chromosome: | 2p11.2 |
| Cancer protein type: | UNCLEAR |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | UNCLEAR |
| Number of cancer specimens: | 19535 |
| Percent of cancer specimens with mutations: | 0.8 |
| Normal role description: | Involved in brown fat metabolism, spermatogenesis, and androgen signalling. Demethylates H3 and therefore upregulates transcription of target genes. Implicated in truncal obeisity but role not established in oncogenesis |