Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | USP15 |
| Gene Name: | USP15 |
| Protein Full Name: | Ubiquitin carboxyl-terminal hydrolase 15 |
| Alias: | Deubiquitinating enzyme; Deubiquitinating enzyme 15; KIAA0529; Ubiquitin carboxyl-terminal hydrolase 15; Ubiquitin specific peptidase 15; Ubiquitin specific protease 15; Ubiquitin thioesterase 15; Ubiquitin thiolesterase 15; Ubiquitin-specific-processing protease 15; UBP15; Unph-2; Unph4 |
| Mass (Da): | 112419 |
| Number AA: | 981 |
| UniProt ID: | Q9Y4E8 |
| Locus ID: | 9958 |
| COSMIC ID: | USP15 |
| Gene location on chromosome: | 12q14.1 |
| Cancer protein type: | TSP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | MIXED |
| Number of cancer specimens: | 20149 |
| Percent of cancer specimens with mutations: | 0.71 |
| Normal role description: | USP15 is a regulatory protein with deubiquitinating specific protease activity. USP15 is able to target mono- or poly-ubiquitinated protein and prevents proteasomal degradation. Specific targets of USP15 include Rbx1, APC tumour suppressor protein and IkBa inhibitior of NF-kB. USP15 has a role in tumourigenesis and was found to be a be implicated in cervical, ovarian, and gastro-intestinal cancers. In ovarian cancer USP15 was found to stabilize Caspase-3 to promote apoptosis, thus classifying USP15 as a tumour suppressor protein. However, USP15 could promote Human papillomavirus-mediated transformation of cervical cells through stabilizing viral oncoprotein E6 to cause degradation of cellular p53 and Rb tumour suppressor proteins. |