Cancer Protein Description
This report provides a detailed description of a selected cancer protein with information collected from various sources, including UniProt, the Wellcome Trust Sanger Institute’s Catalogue of Somatic Mutations in Cancer (COSMIC), and the Atlas of Genetics and Cytogenetics in Oncology and Haematology.
| Protein Name: | LOXL2 |
| Gene Name: | LOXL2 |
| Protein Full Name: | Lysyl oxidase homolog 2 |
| Alias: | Lysyl oxidase-like protein 2;Lysyl oxidase-related protein 2;Lysyl oxidase-related protein WS9-14 |
| Mass (Da): | 86725 |
| Number AA: | 774 |
| UniProt ID: | Q9Y4K0 |
| Locus ID: | 4017 |
| COSMIC ID: | LOXL2 |
| Gene location on chromosome: | 8p21.3 |
| Cancer protein type: | OP? |
| Effect of cancer mutation on protein: | UNCLEAR |
| Effect of active protein on cancer: | PROMOTES |
| Number of cancer specimens: | 19762 |
| Percent of cancer specimens with mutations: | 0.93 |
| Normal role description: | LOXL2 is a lysl oxidase protein. It is involved in the catalysis of crosslinks between collagens and elastin. It also involved in elastin fibre assembly and maturation. It may have additional roles in developmental regulation, senescence, cell growth, and chemotaxis. It is implicated in promoting cancer cell adhesion, migration, invasion and metastases. |